Shameem Sultana Syeda
Research Assistant Professor
Contact
Email
Office Phone
Office Address
475 717 Delaware St SE
Minneapolis, MN 55414
United States
Links:
Titles
Research Assistant Professor, Department of Medicinal Chemistry
Education
Organic Chemistry, Indian Institute of Chemical Technology, India, 2006
Chemistry, Osmania University, India, 2000
Chemistry and Biology, Osmania University, India, 1998
Summary
I received a PhD in Synthetic Organic Chemistry specializing in natural products synthesis and development of new reactions. My current research focuses on the development of Na,K-ATPase a4 inhibitors as male contraceptive agents. My areas of expertise include multi-step synthesis, natural products-based drug design, contract research, development of medicinal chemistry strategies and execution of tactics to generate lead molecules.
Professional Associations
American Chemical Society (ACS) – Organic and Medicinal Chemistry Division
Research
Research Summary/Interests
Synthesis and development of new methodologies, medicinal chemistry.
Patents
Gustavo Blanco, Gunda Georg, Shameem Syeda. Contraceptive agents. US20140005132 A1. Filed07/02/2013. Published January 2, 2014. Issued June 6, 2017.
Publications
Syeda, S. S.; Hong, K. H.; Georg, G. I.; Sanchez, G.; McDermott, J. P.; Blanco, G., The Na+ and K+ transport system of sperm (ATP1A4) is essential for male fertility and an attractive target for male contraception†. Biol Reprod 2020, 103 (2), 343-356.
Syeda, S. S.; Sánchez, G.; Hong, K. H.; Hawkinson, J. E.; Georg, G. I.; Blanco, G. Design, Synthesis, and in Vitro and in Vivo Evaluation of Ouabain Analogues as Potent and Selective Na,K-ATPase ?4 Isoform Inhibitors for Male Contraception. J. Med. Chem. 2018, 61, 1800-1820. DOI: 10.1021/acs.jmedchem.7b00925
Most read article: Article views between January 1 and July 31st, 2019: 6,899 (Source ACS).
Selected for 2018 ACS PressPac: “Prospective birth control pill for men has its origin in an arrow poison.”
Selected for cover page: Syeda, S. S.; Carlson, E. J.; Miller, M. R.; Francis, R.; Clapham, D. E.; Lishko, P. V.; Hawkinson, J. E.; Hook, D.; Georg, G. I. The Fungal Sexual Hormone Sirenin Activates the Human CatSper Channel Complex. ACS Chem. Biol. 2016, 11, 452-459. DOI: 10.1021/acschembio.5b00748
Recommended in F1000Prime as being of special significance in its field: Syeda, S. S.; Rice, D.; Hook, D. J.; Heckert, L. L.; Georg, G. I. Synthesis of Arylazide- and Diazirine-Containing CrAsH-EDT2 Photoaffinity Probes. Arch. Pharm. 2016, 349, 233-241.DOI: 10.1002/ardp.201500440
Among the top 20 downloaded articles in Arch. Pharm (one year after publication): Syeda, S.S.; Jakkaraj, S.; Georg, G.I. Scalable syntheses of the BET bromodomain inhibitor JQ1. Tet. Lett. 2015, 56, 3454-3457.DOI: 10.1016/j/tetlet.2015.02.062