About Scientific Services

Institute for Therapeutics Discovery and Development (ITDD): Translational Services

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Step 1a: Drug Discovery and Lead Optimization

  • Assay Development
  • High-Throughput Screening
    • Screening Library: over 300,000 compounds
  • High Content Screening
  • Fragment Based Screening
  • In Silico (virtual) Screening
  • Hit Characterization
    • Analytical, Biophysical, Biochemical, Cell-Based
  • X-Ray Crystallography*
    • *through collaborations

Step 1b: Drug Discovery and Lead Optimization

  • SAR by Commerce
  • Hit-to-Lead Development
  • Computational Drug Design
  • Drug-Like Properties Optimization
  • Efficacy & Pharmacokinetics
  • Prodrug Design

(Projects can enter at any stage)

Step 2: Pre-Clinical Research

Clinical Candidate Identified

  • Scale Up Drug Synthesis
  • Formulation Studies*
    • *through collaborations
  • CMC-Enabling Studies
    • Drug Synthesis (API)
    • Analytical Development
    • Process Development
    • Reference Standard
    • Stability Studies
  • GLP Batch Manufacturing
  • Safety Pharmacology

Step 3: Clinical Research

Investigational New Drug (IND) Filing

  • GMP Drug Manufacturing

(Available to internal and external investigators)

Research Services Focused On Small-Molecule Drug Discovery And Development

Biological and Screening Services

  • High Throughput Screening
  • Fragment-Based Screening
  • Compound profiling for potency and selectivity
  • Low and High throughput assay development and validation
  • Standard biochemical assays – absorbance, luminescence, fluorescence
  • Specialized biochemical assays – AlphaScreen, mobility shift, chemiluminescent ELISA
  • Biophysical assays – SPR, wavelength shift, ITC
  • Cell-based assays - High Content Analysis (HCA/HCS), FLIPR
  • Kinases, enzymes, epigenetics, protein-protein interactions, ion channels, GPCRs
  • Screening library containing 250,000 compounds
  • Focused libraries and fragment libraries available for screening
  • Biosafety level 3 (BSL-3) assay development and screening

Medicinal, Organic, and Process Chemistry

  • Structure-Activity Relationship (SAR)
  • Lead and Probe Optimization
  • Parallel synthesis and chemical library production
  • Total and multi-step synthesis of natural products
  • Rational, protein-structure based and computational drug design
  • Synthesis of lead molecules, drug candidates and advanced intermediates on a diverse scale (mg to kg)
  • Chemical process development, scale-up and optimization
  • Active Pharmaceutical Ingredients (API) synthesis under cGMP conditions (mg to kg) to support pre-clinical and Phases I-II clinical trials
  • API stability testing
  • Protein purification

Analytical and Purification Chemistry

  • Structure identification and characterization of chemical compounds (IR, NMR [1H, 13C, 19F, 31P, COSY, NOESY, ROESY, HMBC, HMQC], HR-MS, direct infusion MS, optical rotation)
  • Analytical method development (HPLC, UPLC, MS, LCMS)
  • Standard Quality Control analyses (IR, MS, HPLC, UPLC, LCMS, NMR, optical rotation)
  • High-throughput purification of chemical libraries
  • Large scale purification of natural products

Regulatory Support (with IND/IDE Assistance Program and MCT)

  • Investigational New Drug (IND) application support
  • Preparation and/or revision of IND’s Chemistry, Manufacturing and Control (CMC) section for regulatory submission


Vadim J. Gurvich, Associate Director
Telephone:  612-624-4728
Fax:  612-626-6862
Email:  [email protected]