Equipment for Assay Development and Screening


Detection Equipment

 

GE Biacore S200

GE Biacore S200
This label-free system is used for molecular interaction analysis in basic research, drug discovery and development research. The surface plasmon resonance (SPR) instrument detects ligand binding to immobilized macromolecules. When a ligand binds to molecules immobilized on the sensor surface, the SPR sensorgram traces the association and dissociation of the complex, revealing the kinetics of the interaction and affinity values.  Any publications and other research reports which arise from experiments conducted using this instrument must acknowledge the Shared Instrument Grant award 1S10OD021539-01.

Molecular Devices FLIPR® Tetra 384- Well Intracellular Fluorescence Imaging System

Molecular Devices FLIPR® Tetra 384- Well Intracellular Fluorescence Imaging System
The FLIPR® Tetra high throughput cellular screening system is an industry-renowned, flexible, and reliable real-time kinetic cellular assay screening system for identifying early leads against GPCRs and ion channels.
The system features simultaneous pipette and read capability, which makes the system ideal for fast kinetic cellular assays, such as calcium flux.

Interior Liquid Handling Unit of FLIPR Tetra

Interior Liquid Handling Unit of FLIPR Tetra
The system is equipped with a fluorescence camera and a 384-pipettor head.

Molecular Devices SpectraMax M2e plate reader

Molecular Devices SpectraMax M2e plate reader
This monochromator-based plate reader is capable of a variety of read modes: Absorbance, Luminescence, Fluorescence Intensity and Time-Resolved Fluorescence. It features a flash lamp light source, fully-tunable for spectra capture and a cuvette port, with top or bottom read capabilities in 6- to 384- well plates.

Perkin Elmer Enspire

Perkin Elmer Enspire
This 384-well instrument incorporates two distinct reading modes: AlphaScreen and the Corning Epic optical wavelength shift technology. AlphaScreen is a chemiluminescent proximity binding assay in which donor and acceptor beads are brought together in close proximity by binding partners attached to the beads. Using an optical wavelength grating, the Enspire also detects the shift in the wavelength of refracted light due to binding events in biochemical assays or dynamic mass redistribution in cell-based assays.

Liquid Handlers

 

Beckman FX 96 and 384: Class II biological safety cabinet

Beckman FX 96 and 384: Class II biological safety cabinet
The Beckman FX 96 and 384 are dual pod liquid handling systems with supply carousels in Class II biological safety cabinet

Beckman FX 96 and 384: Tissue Culture Laboratory

Beckman FX 96 and 384: Tissue Culture Laboratory
The Beckman FX 96 and 384is a dual pod liquid handling systems with supply carousel in Tissue Culture Laboratory

LabCyte ECHO550

LabCyte ECHO550
The LabCyte ECHO550 is an acoustic focused contactless nanoliter dispensing system

WellPro 3000 96- and 384

WellPro 3000 96- and 384
The WellPro 3000 96- and 384 are well serial diluters

Thermo Multidrop Combi

Thermo Multidrop Combi
The Thermo Multidrop Combi is a single-channel bulk liquid dispenser capable of dispensing into 96-, 384- and 1536-well microplates

Thermo Matrix WellMate

Thermo Matrix WellMate
Thermo Matrix WellMate is a single-channel bulk liquid dispenser capable of dispensing into 6- through 384-well microplates equipped with a stacker for repetitive bulk-filling of plates